Publications

2017

2016

2015

  • Ozel, M.N., Langen, M., Hassan, B.A. and Hiesinger, P.R. (2015) Filopodial Dynamics and Growth Cone Stabilization in Drosophila Visual Circuit Development. eLife, e10721
  • Hassan, B.A. and Hiesinger, P.R. (2015) Beyond Molecular Codes: Simple Rules to Wire Complex Brain. Cell, 163(2):285-291 | [PDF]
  • Langen, M.*, Agi, E.*, Altschuler, D., Wu, L.*, Altschuler, S.*, and Hiesinger, P.R.* (2015) The Developmental Rules of Neural Superposition. Cell, 162(1):120-33 | [PDF] | [Suppl. Materials PDF]
      Highlighted in: Wernet, M.F. and Desplan, C. (2015) Brain Wiring in the Fourth Dimension | Cell [PDF]

2014

  • Agi, E., Langen, M., Altschuler, S., Wu, L., Zimmermann, T., and Hiesinger, P.R. (2014) The Evolution and Development of Neural Superposition, J. Neurogenetics, 28(3-4):216-32. | [PDF]
  • Wang, D., Epstein, D., Khalaf, O., Srinivasan, S., Williamson, W.R., Fayyazuddin, A., Quiocho, F.A., and Hiesinger, P.R. (2014). Calcium/Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1. J. Cell. Biol. 205(1):21-31. | [PDF] | [Suppl. Mat. PDF]
      Highlighted in: Vavassori and Mayer (2014) J.Cell Biol. 205(1):7-99 | [PDF]
  • Zschatzsch, M., Oliva, C., Langen, M., De Geest, N., Ozel, M.N., Williamson , W.R., Lemon, W., Soldano, A., Munck, S., Hiesinger P.R., Sanchez-Soriano, N., Hassan, B. (2014) Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor Signaling. eLife, 3:e01699. | [PDF]

2013

  • Cherry, S., Jin, E.J., Ozel, M.N., Lu, Z., Agi, E., Wang, D., Meinertzhagen, I.A., Chan, C.-C., and Hiesinger, P.R. 2013. Charcot-Maire-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of function. eLife, 2(0):e01064 | [PDF]
      Highlighted in: Sadandappa, M.K. and Ramaswami, M. (2013) eLife e01820 | [PDF]
  • Wang, D. and Hiesinger, P.R. (2013). The vesicular ATPase: a missing link between acidification and exocytosis. J. Cell. Biol., 203(2):171-3 | [PDF]
  • Bezprozvanny, I., and Hiesinger, P.R. (2013). The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration. Mol. Neurodegeneration, 8:23. | [PDF]
  • Carrerira-Rosario, A., Scoggin, S., Shalaby, N.A., Williams, N.D., Hiesinger, P.R. and Buszczak, M. (2013). Recombineering Homologous Recombination Constructs in Drosophila. J. Vis. Exp., in press. | [PDF] | [video link]
  • Wang, D., Chan, C.C., Cherry, S. and Hiesinger, P.R. (2013). Membrane trafficking in Neuronal Maintenance and Degeneration. Cell. Mol. Life Sci., 70(16):2919-34. | [PDF]

2012

  • Williamson, W.R., Chan, C.C., and Hiesinger, P.R. (2012). Subcellular Resolution Imaging in Neural Circuits. Bookchapter in: The Making and Un-Making of Neuronal Circuits, Bassem Hassan, Editor, Humana Press, p.61-90 | [PDF]
  • Jin, E.J., Chan, C.C., Agi, E., Cherry, S., Hanacik, E., Buszczak, M., and Hiesinger, P.R. (2012). Similarities of Drosophila rab GTPases Based on Expression Profiling: Completion and Analysis of the rab-Gal4 Kit. PLoS One, 7(7):e40912 | [PDF]
  • Coen, K. Flannagan, R.S., Carraro-Lacroix, L.R., Wang, D., Vermeire, W., Michiels, C. Munck, S., Sugita, S., Hiesinger, P.R. Grinstein, S., Annaert, W. (2012) Endo-lysosomal dysfunction in PSEN-deficient cells is caused by defects in lysosomal calcium homeostasis and not by defective proton pump function. J. Cell Biol., 198(1):23-35 | [PDF]
  • Wang, D., and Hiesinger, P.R. (2012). Autophagy, Neuron-Specific Degradation and Neurodegeneration. Autophagy, 8(4):711-3 | [PDF]
  • Haberman, A.S., Williamson, W.R., Epstein, D., Wang, D., Rina, S., Meinertzhagen, I.A. and Hiesinger, P.R. (2012). The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration in Drosophila. J. Cell. Biol., 196, 261-276. | [PDF] | [PDF] | [Cover]
  • Chan, C.C., Scoggin, S., Hiesinger, P.R.* and Buszczak, M.* (2012). Combining recombineering and ends-out homologous recombination to systematically characterize Drosophila gene families: rab GTPases as a case study. Comm. Integr. Biol., 5(2):179-83 * co-corresponding authors | [PDF]

2011

  • Chan, C.C., Scoggin, S., Wang, D., Cherry, S., Dembo, T., Greenberg, B., Jin, E.J., Kuey, C., Lopez, A., Mehta, S.Q., Perkins, T.J., Brankatschk, M., Rothenfluh, A., Buszczak, M.*, and Hiesinger, P.R.* (2011). Systematic Discovery of Rab GTPases with Synaptic Functions in Drosophila. Current Biology, 21(20):1704-15. * co-corresponding authors | [PDF] | [Supplemental Materials PDF]
      Highlighted in: Harris, K.P. and Littleton, J.T. (2011) Vesicle Trafficking: A Rab Family Profile. Curr. Biol. 21(20):841-843. | [Dispatch PDF]
  • Chan, C.C., Epstein, D., and Hiesinger, P.R. (2011). Intracellular Trafficking in Drosophila Visual System Development: A Basis for Pattern Formation through Simple Mechanisms. Dev. Neurobiol., 71(12):1227-45. | [PDF]
  • Smibert, P., Bejarano, F., Wang, D., Garaulet, D.L., Yang, J.-S., Martin, R., Bortolamiol-Becet, D., Robine, N., Hiesinger, P.R. and Lai, E.C.. (2011) A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs. RNA, 17(11):1997-2010 | [PDF]

2010

  • Williamson, W.R., Yang, T., Terman, J.R., and Hiesinger, P.R. (2010). Guidance Receptor Degradation is Required for Neuronal Connectivity in the Drosophila Nervous System. PLoS Biology, 8(12):e1000553 [PDF] | [Cover]
  • Williamson, W.R. and Hiesinger, P.R. (2010). On the role of v-ATPase V0a1-dependent degradation in Alzheimer Disease. Comm. Int. Biol. (in press) [PDF]
  • Williamson, W.R., Wang, D., Haberman, A.S. and Hiesinger, P.R. (2010). A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila photoreceptors. J. Cell. Biol., 189: 885-99. [PDF] | [Cover]
      Highlighted in: In Focus Article 'The acid test of v-ATPase function' by Ben Short, J. Cell. Biol. 189:773. [PDF]
  • Williamson, W.R. and Hiesinger, P.R. (2010). Preparation of Developing and Adult Drosophila Brains and Retinae for Live Imaging. Journal of Visualized Experiments, 37. doi:10.3791/1936. [PDF] | [video link]

2009

  • Hiesinger, P.R. and Meinertzhagen, I.A. (2009) Visual System Development: Invertebrates. in: Squire LR (ed.) Encyclopedia of Neuroscience, volume 10, pp. 313-322. Oxford: Academic Press, Elsevier. [PDF]

2008

  • Williamson, W.R. and Hiesinger, P.R. (2008)
    Synaptic Patterning by Morphogen Signaling. Science Signaling, 1(18):pe20. [PDF]
  • Zhai, R.G., Zhang, F., Hiesinger, P.R., Cao, Y., Haeuter, C.M., and Bellen, H.J. (2008)
    NAD Synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature, 452:887-91. [PDF]
  • Zhang, W., Wang, D., Volk, E., Bellen, H.J., Hiesinger, P.R.*, Quiocho, F.A.* (2008) * co-corresponding authors
    v-ATPase V0 sector subunit a1 in neurons is a target of calmodulin. Journal of Biological Chemistry, in press.   [ PDF ] .
  • Fischbach, K.F. and Hiesinger, P.R. (2007)
    Optic Lobe Development, in Brain Development of Drosophia, Ed. G. Technau, Landes Biosciences.   [ Pre-print PDF ] | [ Publisher link ]

2007

  • Zhang, J., Schulze, K.L., Hiesinger, P.R., Suyama, K., Wang, S., Fish, M., Acar, M., Hoskins, R.A., Bellen, H.J., and Scott, M.P. (2007)
    31 Flavors of Drosophila Rab Proteins. Genetics 176:1307-1322.   [ PDF ] | [ PDF suppl ]

2006

  • Zhai, R.G., Cao, Y., Hiesinger, P.R., Mehta, S.Q., Schulze, K.L., Verstreken, P., Zhou, Y. and Bellen, H.J. (2006)
    Drosophila NMNAT Maintains Neural Integrity Independent of its NAD Synthesis Activity. PloS Biology 4(12):e416. [PDF]
  • Hiesinger, P.R.* #, Zhai, R.G.*, Zhou, Y., Koh, T.-W., Mehta, S.Q., Verstreken, P., Schulze, K.L., Cao, Y., Fischbach, K.-F., Meinertzhagen, I.A., and Bellen, H.J.#, (2006) *co-first authors, # corresponding authors
    Activity-independent prespecification of synaptic partners in the visual map of Drosophila Curr. Biol., 16, 1835-43 [PDF] | [PDF suppl]
  • Fayyazuddin, A., Zaheer, M., Hiesinger, P.R., and Bellen, H.J. (2006)
    giant fiber A (gfA) encodes a nicotinic acetylcholine receptor that mediates synaptic transmission in the giant fiber circuit of Drosophila.PloS Biology 4(3):e63. [PDF]

2005

  • Hiesinger, P.R. and Hassan, B.A. (2005).
    Genetics in the Age of Systems Biology. Cell, 123, 1173-4. [PDF]
  • Hiesinger, P.R., Fayyazuddin, A., Mehta, S.Q., Rosenmund, T., Schulze, K.L., Zhai, R.G., Verstreken, P., Cao, Y., Zhou, Y., Kunz, J., and Bellen, H.J. ( 2005).
    The v-ATPase V0 subunit is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell 121, 607-620. Cover article. [PDF] | [PDF suppl] | [Cover]
     Preview in Cell 121, 496-497. Bajjalieh, S.A new view of an old pore.
  • Mehta, S.Q.*, Hiesinger, P.R.*, Beronja, S., Zhai, R.G., Schulze, K.L., Verstreken, P., Cao, Y., Zhou, Y. Tepass, U., Crair, M.C., and Bellen, H.J. (2005). *co-first authors
    Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46, 219-232. [PDF]
     Preview in Neuron 46, 164-166. Clandinin, T.R. Surprising twists to exocyst function.

2004

  • Meinertzhagen I.A. and Hiesinger, P.R. (2004).
    Visual system development, invertebrates. Elsevier’s Encyclopedia of Neuroscience [link]
  • Hiesinger, P.R. and Bellen H.J.(2004).
    Flying in the face of total disruption. Nature Genetics 36, 211-212. [PDF]
  • Bellen, H.J., Levis, R.W., Liao, G., He, Y., Carlson, J.W., Tsang, G., Evans-Holm, M., Hiesinger, P.R., Schulze, K.L., Rubin, G.M., Hoskins, R.A., and Spradling, A.C. (2004).
    The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167, 761-781. [PDF]

2003

  • Zhai, R.G.*, Hiesinger, P.R.*, Koh, T.-W., Verstreken, P., Schulze, K.L., Cao, Y., Jafar-Nejad, H., Norga, K.K., Pan, H., Bayat, V., Greenbaum, M.P., and Bellen, H.J. (2003). *co-first authors
    Mapping Drosophila mutations with molecularly defined P element insertions. Proc. Natl. Acad. Sci. USA 100, 10860-10865. [PDF]
      Featured Highlight in Nature Reviews Genetics 4, 849. Casci, T. I can name it in three...
  • Verstreken, P., Koh, T.-W., Schulze, K.L., Zhai, R.G., Hiesinger, P.R., Zhou, Y., Mehta, S.Q., Cao, Y., Roos, J., and Bellen, H.J. (2003).
    Synaptojanin is recruited by Endophilin to promote synaptic vesicle uncoating. Neuron 40, 733-748. [PDF]
      Preview in Neuron 40, 665-667. Song, W. and Zinsmaier, K.E. Endophilin and Synaptojanin hook up to promote synaptic vesicle endocytosis.
  • Fabian-Fine, R., Verstreken, P., Hiesinger, P.R., Horne, J.A., Kostyleva, R., Zhou, Y., Bellen, H.J., and Meinertzhagen, I.A. (2003).
    Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. J. Neurosci. 23, 10732-10744. Cover article. [PDF] | [Cover]

2002

  • Morales, J., Hiesinger, P.R., Schroeder, A.J., Kume, K., Verstreken, P., Jackson, F.R., Nelson, D.L., and Hassan, B.A. (2002).
    Drosophila Fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34, 961-972. [PDF]
  • Pennetta, G., Hiesinger, P.R., Fabian-Fine, R., Meinertzhagen, I.A., and Bellen H.J. (2002).
    Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron 35, 291-306. Cover article. [PDF] | [Cover]
  • Kango-Singh, M., Nolo, R., Tao, C., Verstreken, P., Hiesinger, P.R., Bellen, H.J., and Halder, G. (2002).
    Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719-5730. Cover article. [PDF] | [Cover]

1999-2001

  • Hiesinger, P.R.* , Scholz, M.*, Meinertzhagen, I.A., Fischbach, K.-F., and Obermayer, K. (2001). *co-first and corresponding authors
    Visualization of synaptic markers in the optic lobe neuropils of Drosophila using a new constrained deconvolution method. J. Comp. Neurol. 429, 277-288. [PDF]
  • Hiesinger, P.R. (2000).
    The evolution of the millenium bug. Riv. Biol./Biology Forum 93, 169-174.
  • Hiesinger, P.R., Reiter, C., Schau, H., and Fischbach, K.-F. (1999).
    Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila optic lobe development depend on synaptobrevin. J. Neurosci. 19, 7548-7556. Cover article. [PDF]
  • Laissue, P.P., Reiter, C., Hiesinger, P.R., Halter, S., Fischbach, K.-F., and Stocker, R.F. (1999).
    Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster. J. Comp. Neurol. 405, 543-552. [PDF]